As per vedic astrology Sixth place is only responsible for disease. Sixth lordship is also responsible for disease.
For example if sixth lord is Sun native will be suffered by Heart related issues.
If sixth house lord is Moon native will be suffered by cold, mind related issues.
If sixth lord is Mars native will be suffered Blood related issues. Fire Accident , blood losses will happen.
If sixth lord has conjunction with Rahu native will be suffered by virus attack.
If sixth lord is Guru native will be suffered by kidney related issues. He has also obstacles in progeny
If sixth lord is Saturn he will be suffered by Neurological issues.
If sixth lord is Mercury he will faces mind related issues. He will have obstacles while he speaking.
If sixth lord has conjunction with Kethu native will be suffered virus attack & cancer .
If sixth lord is Venus native will faces sex related issues.
For decision making there is need for Wisdom & experience. Wisdom is given by 5 th lord, experience is given by 3 & lagna lord. So if there is a combination of Lagna lord , 3 rd house lord & 5 th lord sure that person will be expert in all subjects ( Guru , Mercury & Kethu position should be considered. )